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Se also reduces the incidence of autoimmune thyroiditis and other related conditions, and the reduction of thyroid autoimmune effects is related to the role of GPX and thioredoxin reductase (TrxR) as antioxidant defense systems that scavenge ROS and excess H 2 O 2 produced by thyroid cells during thyroid hormone synthesis, which can lead to thyroid cell necrosis and increased macrophage invasion in severe nutritional Se deficiency (Duntas, 2006)
Tang et al., 2014)
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In the STEP 1 semaglutide trial (Wilding et al., NEJM , 2021) and the SURMOUNT-1 tirzepatide trial (Jastreboff et al., NEJM , 2022), nausea affected roughly 44% of semaglutide patients and about 24% of tirzepatide patients at the maximum dose
