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The SURMOUNT trials evaluating tirzepatide showed similar outcomes: discontinuation led to significant weight rebound despite ongoing diet and exercise efforts
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Elevated levels of MTA and SAMe are tightly linked to T-cell exhaustion in hepatocellular carcinoma (HCC), and deletion of a key SAMe-producing enzyme MAT2A results in inhibition of T-cell exhaustion and limitation of HCC growth in mice (86)
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