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Phase 2 clinical trial data published in the New England Journal of Medicine (Jastreboff et al., 2023) demonstrated mean body weight reductions of up to approximately 24% over 48 weeks in adults with obesity a notable finding, though long-term durability data and head-to-head comparisons with other treatments are not yet available

After the completion of the study, it was noted that there appeared to be a significant reduction in the body weight of these murine models, including a reduction of excess body lipids

The mysterious mythic melatonin morass [PMID: 8935364] Laboratory literature summary: "Macbeth does murder sleep"

Weeks 13 through 16 escalate to 8mg once weekly