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Peripheral brain-derived neurotrophic factor (BDNF) as a biomarker in bipolar disorder: a meta-analysis of 52 studies
1,2,6 Neurologic manifestations are caused by progressive demyelination and can include peripheral neuropathy, areflexia, and the loss of proprioception and vibratory sense
But their impact is set to extend far beyond just blood sugar control
Oral small molecules beyond orforglipron, additional dual agonists, and standalone amylin agents are all in Phase 2, reflecting a field that is no longer betting on one approach
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