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10) indicate a complex interaction between NFT derivatives and the Nrf2 pathway
Incorporation of small, sterically optimized substituents that interact with these residues may reduce off-target activity
Given that distinct microbial derivatives act through unique molecular targets and pathways to regulate the enteric nervous system (ENS), this review adopts a categorical approach to elucidate the mechanisms underlying their crosstalk more clearly within the gut microbiota-ENS axis ( Figure 3 )
That agility addresses a structural failure in generic injectable manufacturing: drugs go into shortage because manufacturers with thin margins on high-volume, low-price products have no incentive to invest in excess capacity
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