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This early weight loss is often due to reduced appetite and smaller portion sizes
Increasing research investments and successful commercialization of oral formulations are accelerating market acceptance
Furthermore, it increases the risk of osteoporosis and fractures, especially in post-menopausal women,83 and its extended use has been associated with a potential increase in bladder cancer.84 In conclusion, although pioglitazone can be used for any degree of CKD, its adverse effects (oedema, heart failure, fractures, risk of bladder carcinoma) limit its indication in patients with the aforementioned disease
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