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Zepbound (tirzepatide) is a glucagon-like peptide-1 (GLP-1) and glucose-dependent insulinotropic polypeptide (GIP) receptor agonist that is FDA-approved along with increased physical activity and a reduced-calorie diet for chronic weight management in adults with a starting body mass index (BMI) of: 30 kg/m^2 or higher (obesity) or 27 kg/m^2 or higher (overweight) with at least one weight-related condition such as high cholesterol, high blood pressure (hypertension), type 2 diabetes, heart disease, or obstructive sleep apnea
This three-phase randomized controlled clinical trial involves 1961 overweight or obese adults (none of them suffering from diabetes, average weight 105 kg, average body mass index 38 kg/m2), the clinical trial was conducted at 129 sites in 16 countries in Asia, Europe, and North and South America
Everyone gains from the careful watch that finds problems early
Regier EE, Venkat MV, Close KL
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