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Because the pathogenesis of active TB meningitis involves both CNS-resident and peripheral immune mechanisms 32,33 , the complementary use of brain organoids and PBMCs allowed us to capture these interacting compartments and demonstrate human-relevant immunomodulatory effects
Clinical Pharmacokinetics Methionine is primarily metabolized in the liver
Its sequence Ac-Nle-cyclo[Asp-His-D-Phe-Arg-Trp-Lys]-NH incorporates a norleucine substitution, a D-phenylalanine substitution and a lactam bridge that cyclises the molecule
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