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Some lean mass loss occurs with any significant weight loss, but the glucagon receptor activation in both compounds may help preserve muscle compared to GLP-1-only approaches
Alcohol consumption can affect glycemic control, and the combination of GLP-1 therapy with alcohol might increase hypoglycemia risk, particularly in patients taking concomitant insulin or sulfonylureas
With tesamorelin
Pooled semaglutide data showed a significant reduction of 32% in risk of stroke compared with placebo
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