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This estrogen loss is especially observed when women approach peri- and postmenopause [9] and has a profound impact on dermal health and affects almost all organ systems, which has an overall negative influence on womens quality of life (QOL) [10]

As the main transportation and storage protein of Se, low levels of Se-P will also ensure Se concentration in various tissues in the event of Se deficiency and disease (121)

However, a thorough evaluation to identify and address reversible causes of inadequate weight losssuch as maladaptive eating behaviors, inadequate physical activity, or anatomical issues like gastrogastric fistulashould always precede medication initiation

Severe renal impairment, a personal or family history of medullary thyroid carcinoma, and pancreatitis are contraindications from the start