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In healthy individuals, CBF is tightly coupled to the metabolic demands of neurons (Claassen et al., 2021), however, it is unclear whether reduced CBF in ADRD is a cause or consequence of cerebral hypometabolism
Collectively, these results confirmed the effective tumor accumulation and long retention ability of the NPs, which are owing to both the RGD-mediated targeting attachment and enhanced permeability and retention (EPR) effect
PMCID: PMC1130894
One reviewer described severe symptoms including vomiting and headache after taking a single capsule
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