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February 22, 2026

Unreported Symptoms While the population the researchers studied is admittedly not representative Reddit users are younger, more likely to be male and disproportionately based in the United States the symptoms described in their collective accounts largely match the known side effects of semaglutide and tirzepatide: about 44% of users in the study described at least one side effect, most commonly some form of gastrointestinal distress

These findings support the role of GLP-1 receptor agonists as a rescue therapy in adolescents with post-LSG weight regain, particularly when hormonal attenuation and anatomical dilation coexist

Nevertheless, GIPR antagonist is now available on the market with promising initial results, and can be utilised to understand the clinical benefits seen with tirzepatide