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Daily doses for extended periods (months to years) push into territory where chronic effects could emerge without warning
Reconstitute the full amount, divide into weekly aliquots in sterile glass vials, freeze all except the current week portion, and thaw one new aliquot each week
4.4 Pharmacokinetic parameters in beagle dogs after intravenous and intramuscular administration In this part of the experiment, three male and three female beagles were examined for four cycles
Neurosci Biobehav Rev
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