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Over 1 in 3 people taking GLP-1s face barriers to access, including difficulty filling prescriptions most often due to shortages
For most adults, initial dual therapy is recommended: Metformin + SGLT-2 inhibitor Treatment should then be individualized based on comorbidities: Atherosclerotic cardiovascular disease: consider adding GLP-1 receptor agonists such as semaglutide Chronic kidney disease: SGLT-2 inhibitors remain foundational, with DPP-4 inhibitors as additional options when needed
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