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A common functional polymorphism at codons 108 and 158 in the genes coding for SCOMT and MBCOMT (COMT Val 108/158 Met), respectively, has been examined in relationship to a number of neurological disorders involving the noradrenergic or dopaminergic systems, such as schizophrenia (Park et al., 2002) or Parkinson's disease (Kunugi et al., 1997)

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Its prolonged half-life makes it a useful reference compound for studying sustained GLP-1 receptor engagement in preclinical in-vitro models