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As discussed above, rodent data are not completely applicable to human pathogenesis, and it has been noted that rodent islet histopathology is remarkably different from what has been observed in human samples (244)
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They enhance insulin secretion, suppress glucagon release, slow gastric emptying, and promote satiety
Crosstalk among these systems is mediated by converging pathways involving calcium signaling, redox homeostasis, inflammatory cascades, and extracellular nucleotide metabolism
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