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Common Cagrilintide Reconstitution Setups Vial Size 5 mg BAC Water 2.0 mL Concentration 2.5 mg/mL 0.6 mg Draw 0.24 mL / 24 units 1.2 mg Draw 0.48 mL / 48 units 2.4 mg Draw 0.96 mL / 96 units 4.5 mg Draw 1.80 mL / 180 units* Vial Size 5 mg BAC Water 3.0 mL Concentration 1.67 mg/mL 0.6 mg Draw 0.36 mL / 36 units 1.2 mg Draw 0.72 mL / 72 units 2.4 mg Draw 1.44 mL / 144 units* 4.5 mg Draw Exceeds vial Vial Size 10 mg BAC Water 2.0 mL Concentration 5.0 mg/mL 0.6 mg Draw 0.12 mL / 12 units 1.2 mg Draw 0.24 mL / 24 units 2.4 mg Draw 0.48 mL / 48 units 4.5 mg Draw 0.90 mL / 90 units Vial Size 10 mg BAC Water 3.0 mL Concentration 3.33 mg/mL 0.6 mg Draw 0.18 mL / 18 units 1.2 mg Draw 0.36 mL / 36 units 2.4 mg Draw 0.72 mL / 72 units 4.5 mg Draw 1.35 mL / 135 units* *Draws above 1.0 mL exceed standard 1 mL U-100 syringe capacity and may require a larger syringe or split injections

When Yuyang Liu, a graduate student in his lab and first author of the study, compared SLC25A39's structure against others in the SLC family of transporters in the AlphaFold protein structure database, Liu spotted a unique extra loop in the protein

GSH has been demonstrated to be not actively transported into the cell except only a few cell types, notably kidney and intestinal epithelial cells [7, 8]

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