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The prognostic impact of the reactive hyperemia index (RHI) in HFpEF patients suggests that endothelial dysfunction may not be merely a passive finding, but rather that endothelial function plays an active and crucial pathophysiological role in HFpEF [23]
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Mixed centrally and peripherally acting anti-obesity medicines with evidence for use in older adults Three GLP-1 receptor agonists are currently approved for obesity pharmacotherapy (Tirzepatide is a dual GIP-GLP-1 receptor agonist)
Clinical studies, including SURMOUNT-4, have shown that patients who discontinue GLP-1 receptor agonists typically regain a significant portion of lost weight within the first year
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