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This has led to interest in NAC for conditions like systemic lupus erythematosus (SLE), where a small RCT found that NAC (2.4-4.8 g/day) improved disease activity scores and reduced anti-dsDNA antibody levels (Lai et al., Lupus, 2012) [42]

Leverage molecular signatures to enrich for patient subgroups most likely to respond to targeted therapies, thereby increasing trial efficiency and improving the likelihood of therapeutic success

Weight Management As described above, berberine has shown some benefits in supporting weight management through the mechanisms described above, especially through its effects on increasing GLP-1 secretion and thereby improving insulin sensitivity and promoting feelings of satiety

As research continues to unravel the complex physiology of fat distribution, it's becoming clear that visceral fat is not just about weightit's about health