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Abstract Glucagon-like peptide 1 (GLP-1)-based therapies, such as semaglutide and tirzepatide, represent highly effective treatment options for people with type 2 diabetes and obesity, enabling effective control of glucose and weight loss, while reducing cardiovascular and renal morbidity and mortality

Another investigation involving 7.5 grams of allulose administered before a meal showed trends toward elevated GLP-1 concentrations, but these findings did not consistently reach statistical significance across all measured time points

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