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Step 1: Completion of Phase 3 Clinical Trials These studies assess: Long term safety and tolerability Consistency of weight loss outcomes Impact on metabolic and cardiovascular markers Real world relevant patient groups Only once sufficient trial evidence exists can a regulatory submission take place

Pheomelanin produces a lighter, yellow-red pigment in place of the dark brown-black eumelanin responsible for hyperpigmentation

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When used in the short term, prednisone can alter gastrointestinal structure and function, says Joseph Michalisin, MD, an orthopedist at Northwell Lenox Hill Hospital in Manhattan