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The anti-cancer properties of biguanides are displayed through several mechanisms of action, including the activation AMPK pathway with the consequent inhibition of mTOR and reduction of several pro-tumorigenic effects including cell proliferation and production of inflammatory mediators (Seyfried et al., 2014
These are laboratory observations only
Moreover, in terms of outcome indicators, the selection centered on "cardioprotection"
Telomere shortening to a critically short length leads to epigenetic defects at mammalian telomeres and subtelomeres, characterized by decreased histone and DNA methylation and increased histone acetylation
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