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Injection (Wegovy 2.4 mg): ~ 14.9% mean weight loss at 68 weeks in adults with overweight/obesity in STEP 1 (NEJM, 2021)
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110,111 Causes of ER expression loss include epigenetic regulation, hypoxia, overexpression of epidermal growth factor receptor (EGFR) or human epidermal growth factor receptor 2 (HER2), and dysregulation of tumor suppressors such as p53 and pRb2/p130
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