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49 Further evaluation on a double-blind, randomized phase 1 clinical trial in 98 patients with T2DM on current management with metformin revealed that Danuglipron was generally well tolerated and associated with minimal side effects such as nausea, dyspepsia, and vomiting comparable with the ones observed with the use of injectable GLP-1RA

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1), and also acts on receptors in pancreatic -cells, myocytes in the sinoatrial node, and Brunners glands in the duodenum(Knudsen et al 2014)

Semaglutide is available in two formulations: a once-weekly subcutaneous injection and a daily oral tablet