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It has been reported that berberine can activate the bitter taste receptor TAS2R38 in enteroendocrine cell lines such as STC-1 and NCI-H716, stimulating GLP-1 secretion in a phospholipase C-dependent manner [22, 28]
Juneja et al., 2020)
They are also not recommended in individuals with certain conditions such as inflammatory bowel disease, pancreatitis, personal or family history of medullary thyroid cancer or multiple endocrine neoplasia
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