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Clinical studies show participants lost an average of 15 to 25 percent of their body weight over several months

The full publication is available for free download for the next 50 days: #PulmonaryHypertension #ChronicKidneyDisease #CardiovascularEvents #RHC Association of borderline pulmonary artery wedge pressure with major cardiovascular events in patients with pulmonary hypertension and chronic kidney disease sciencedirect.com To view or add a comment, sign in CHRONIC MULTI-SYTEM DISEASES ACE2 Loss, GPCRs, and -Arrestin: The Epigenetic Storm Behind Chronic Multi-System Disease When ACE2 levels drop (due to SARS-CoV-2, EBV/Zta, or chronic stress), it sets off a cascade of GPCR overactivation: Angiotensin II / AT1R vasoconstriction, inflammation, oxidative stress Bradykinin / B1R pain, vascular permeability, inflammation Tachykinins / NK1R neuroinflammation, pain, autonomic dysregulation Prostaglandins / EP & DP receptors amplifies PGE2/PGD2-driven inflammatory signaling These GPCRs hyperactivate intracellular pathways like NF-B, MAPK/ERK, CREB, and JAK/STAT leading to epigenetic reprogramming