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It is a partial sequence of a larger protein called BPC, which is present in gastric secretions at nanogram-per-milliliter concentrations 1
A second pathway, ERK1/2 signalling, governs cell survival and fibroblast activity, and appears especially relevant in tissue thats naturally poor in blood supply, tendons and ligament junctions being the clearest examples (Rodgers et al., 2025)
But it could be helpful to screen people for B12 deficiency in advance and give them B12 supplements to delay or prevent the onset of depression
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