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During testosterone replacement therapy, your liver metabolizes both endogenous and exogenous hormones
Glycemic effects remain relevant, particularly in patients with prediabetes or insulin resistance, but they are no longer the defining measure of success
These drugs slow stomach emptying, which can cause gastroparesis (stomach paralysis) in rare cases
It also has a growing research base, with work looking at how engaging these three pathways together shapes metabolic and insulin signaling (Coskun et al., 2022, Cell Metabolism)
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