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Based on the SELECT trial, which enrolled over 17,600 participants across 41 countries and showed a 20% reduction in major adverse cardiovascular events

J Immunol 185:49124920 Zaki MH, Boyd KL, Vogel P, Kastan MB, Lamkanfi M, Kanneganti T-D (2010) The NLRP3 inflammasome protects against loss of epithelial integrity and mortality during experimental colitis