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The GLP-1 market illustrates a specific dynamic: when two large manufacturers with comparable product efficacy compete for formulary position, the rebate competition between them drives gross-to-net discounts to levels that compress both manufacturers net revenue while primarily benefiting the PBMs plan sponsor clients

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Glucagon stimulation can increase heart rate, and elevated pulse rate was observed in trial participants a finding that warrants careful monitoring, particularly in individuals with pre-existing cardiovascular conditions

Patients dont really know what part of the world these med spas are bringing products in from and whether they are diluting it before injecting, said Wolf, the Miami plastic surgeon