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According to the trial protocols, the general rule was that if a dose was missed, it could still be administered within a defined window, usually several days after the scheduled date, without disrupting the escalation plan

Research suggests that gradually improving blood sugar control over several months may reduce the risk of early worsening retinopathy compared to very rapid normalization

GHK-Cu, by contrast, has only preclinical (laboratory and animal) evidence and has not been validated in large-scale human trials

These self-administration reports have brought to light a spectrum of possible side effects, ranging from localized reactions like burning or itching at the injection site to more systemic responses such as fatigue, muscle soreness, and nausea