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The few available human studies are small, unblinded, and often conducted by clinics with a stake in the outcome
Never a spa, always a clinic
Cold sensitivity likely results from metabolic changes associated with weight loss, including reduced adipose tissue insulation, decreased basal metabolic rate, and adaptive thermogenesis from caloric restriction
The authors concluded that both drugs have a small incidence of cardiac dysautonomia as an adverse event, the majority of which was classified as non-serious, but called for more studies
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