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Adequate hydration supports kidney function, helps manage potential side effects, and can help distinguish between hunger and thirst

The decision to initiate tirzepatide should be individualized, taking into account hemodynamic stability, concomitant medications, and overall clinical status, and may warrant multidisciplinary discussion and close monitoring when used soon after an acute cardiovascular event, they wrote

This result was explained by the authors as the lack of hepatocellular ballooning in a more consistent percentage of subjects within the pioglitazone group on initial biopsies as assessed after central review

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