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Therefore, GLP-1RAs have emerged as one of the recommended pharmacological interventions for type 2 diabetes mellitus, especially for patients with cardiovascular risk factors and coexisting comorbidities (e.g., chronic kidney disease) [5]

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however, current evidence remains limited, heterogeneous, and derived largely from secondary analyses or observational studies rather than dedicated randomized heart failure trials

In rare cases, individuals may develop lipohypertrophy (thickening of subcutaneous fat) or lipoatrophy (thinning of subcutaneous fat) at injection sites