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First, human caSMCs also showed a 2-fold increase in cAMP release in response to GLP-1(2836), which was abolished in the presence of the sAC inhibitor KH7, but not the tmAC inhibitor Ddox (Figure 2H)
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Of note, by the end of an 11-day period, EE in control mice weight-matched to the semaglutide group by food restriction was reduced, whereas EE in the semaglutide-treated group returned to baseline levels
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