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Risk assessments for human inhalation toxicity based on traditional animal studies generally include a safety factor of 25 to account for uncertainties related to interspecies (animal-to-human: 2.5-safety factor) and inter-individual (human-to-human: 10-safety factor) variabilities (ECHA, 2012)
X(PC) on procaspase-1 is only fivefold slower than wild-type BoNT/X protease on VAMP1
And it's increasingly stepping out of the generic world and going after big, brand-name drugmakers such as Pfizer and Novo Nordisk
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