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Considering the inflammatory nature of NAFLD, biomarkers such as IL-1, IL-6, IL-8, IL-10, and tumor necrosis factor- are significantly elevated in NAFLD/NASH patients compared with healthy controls and those with simple steatosis, with tumor necrosis factor- notably higher in simple steatosis relative to controls 169

This means at 0.25mg weekly, you will use only 1mg of the 5mg in the vial before the 28-day window closes

KLOW has not been evaluated in formal human clinical trials, so any extrapolation to human safety is speculative

The key to differentiating DILI from AIH lies in whether liver inflammation resolves after stopping the causative drug (153)