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Chronic exendin-4 treatment has shown anxiolytic and antidepressant-like effects in a Parkinson disease model induced by lipopolysaccharide and accompanied by alterations in dopaminergic signaling
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When taken by type 2 diabetics, it reduces fasting glucose concentrations, postprandial glucose levels, food intake, and body weight
In our opinion, the increase in hydrogen sulfide production in glutathione-treated old animals was due to an increase in the expression of 3-MST (by 25%), or probably the activity of this mitochondrial enzyme due to an excess of the substrate L-cysteine, which is common for the synthesis of this gaseous mediator and glutathione
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