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How tirzepatide works (dual GIP/GLP-1 mechanism) Tirzepatide is a dual agonist of two incretin hormone receptors: glucose-dependent insulinotropic polypeptide (GIP) and glucagon-like peptide-1 (GLP-1)
111 A remaining question is whether potential controlling factors including allosteric control of glycogen synthase (GS) and phosphorylases via glucose-6-phosphate (G6P), 112 in addition to the insulin-independent transport of glucose across the hepatocellular plasma membrane by GLUT2 (as a glucose-sensitive protein in liver cells), can impact hepatic glycogen metabolism
Oral versions of these drugs need to be given in much higher doses than injectable versions to withstand digestion
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