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Morita K, Wang F, Patel K, Bueso-Ramos CE, Zahr AA, Gumbs C, Zhang J, Song X, Mendoza M, Wu CJ, Kornblau S, DiNardo CD, Ravandi F, Garcia-Manero G, Jabbour E, Andreeff M , Kantarjian HM, Konopleva M, Futreal A, Takahashi K
7 In fact, xCT is considered to be the main transporter of cystine in cancer (Table 1) 25,26,27 and its expression is controlled by nuclear factor erythroid 2-related factor 2 (NRF2), a master regulator of the cellular redox state, 28 highlighting the importance of xCT in an oxidative stress-resistant cancer cell phenotype
D.et al (2015)
Remodeling phase exhibits improved collagen organization and reduced fibrosis, resulting in stronger, more functional repaired tissue with minimal scarring
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