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Additional strategies under investigation aim to develop small-molecule GLP-1R modulators, sustained-release depot formulations, and combination regimens that pair GLP-1R agonists with complementary agents to maximise metabolic and organ-protective benefits
Continuous GLP-1RA use for three years was associated with the greatest reduction in MACE risk compared with sulfonylureas, whereas interruptions and discontinuations were associated with a progressive attenuation of this protective effect, with risk estimates in some scenarios approaching those of the comparator group
Typical treatment protocols: Cycles of 5 days per week for 1-3 months, followed by 2-4 weeks off
A European Medicines Agency safety review concluded that semaglutide exposure may be associated with approximately a two-fold increase in the relative risk of NAION among adults with type 2 diabetes, translating to roughly one additional case per 10,000 treated patients annually
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