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For those seeking pharmacological weight management, semaglutide (Wegovy) may be considered within NHS specialist weight management services according to NICE TA875 eligibility criteria
Thiamine supplementation mood and cognitive functioning
Other combinations of entero-pancreatic hormones, including cagrisema (GLP-1/amylin RA) and the triple agonist retatrutide (GLP-1/GIP/glucagon RA), have progressed to phase 3 trials as obesity treatments, and early data suggest that they may lead to even greater weight loss than tirzepatide [28]
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