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KPV, the C-terminal -MSH fragment, modulates NF-B signaling and inflammatory-cytokine response in cell-based models
Combined with sensitivity analyses, we infer that the imprecision leading to downgraded evidence quality for certain outcomes may be linked to differences in study follow-up duration: short-term follow-up studies might suffer from increased random error or insufficient statistical power due to inadequate accumulation of cardiovascular events
2 This effect tends to be more severe with shorter-acting GLP-1 RAs
In the Kidney: GLP-1 has a Natriuretic effect
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