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[179] report that de novo variants, although exceedingly rare to find recurrently, play a strong role but should be placed in the context of the gene-based mutation rate and conclude that: the reality that hundreds of modest, common, and rare/strong impact/partially penetrant variants abound in each genome
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The SURPASS-1 trial investigated the efficacy and safety of the three doses of 5, 10, or 15 mg tirzepatide in drug-nave patients with T2D who were not sufficiently controlled with a lifestyle intervention with diet and exercise versus placebo (70)
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