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It is clear that comparative in vivo metabolism and toxicity studies need to be undertaken with AMAP in species other than hamster and mouse, most notably in the rat
These medicines work by mimicking the action of the naturally occurring GLP-1 hormone, which stimulates insulin secretion in response to food intake, suppresses glucagon release, slows gastric emptying, and promotes satiety
Here, we highlight another factor, lack of standardized technique, which may also contribute to translational failure
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