ME/CFS and Genetics: Chronic Fatigue Syndrome Genes, Immune Pathways, and Natural SolutionsGenetic variants in immune, mitochondrial, and inflammatory pathways (NK cells, NLRP3, interferon, complement, TRP channels) increase ME/CFS susceptibility
Summary: Feeling worse after a B12 injection typically reflects your body adjusting to replenished vitamin levels, triggering metabolic processes that may temporarily cause fatigue, headaches, or injection site discomfort
Besides lifestyle changes, drugs that help prevent muscle loss may also be used in combination with GLP-1
However, in tauopathies such as AD, as well as in hibernation, tau undergoes hyperphosphorylation catalyzed by various protein kinases, including but not limited to glycogen GSK3, cyclin-dependent kinase 5 (CDK5), and protein kinase A (PKA) [103,104,105], accumulating an excess of 7-10 phosphate groups [106]