The differential expression of circular RNAs (circRNAs) and microRNAs (miRNAs) in cancer is a useful predictor of their potential role in cancer progression, whether as oncogenes or tumour suppressors [69]
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Multiple cellular processes are considered to contribute to this functional decline and these are collectively referred to as the hallmarks of aging and these include processes like genomic instability, telomere attrition, epigenetic alterations, loss of proteostasis, disabled macroautophagy, deregulated nutrient-sensing, mitochondrial dysfunction, cellular senescence, stem cell exhaustion, altered intercellular communication, chronic inflammation, and dysbiosis 1
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