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NO diffuses into adjacent smooth-muscle cells, stimulates soluble guanylate cyclase, increases cyclic GMP, and lowers intracellular calcium, culminating in vasorelaxation and anti-platelet effects
331,336 Data from three clinical studies (NCT04083222, NCT03714776, and NCT03101878) demonstrated that compared with placebo, IONIS-AGT-LRx significantly reduces plasma AGT levels, with good tolerability and no notable off-target effects
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