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PLoS ONE 15:e0232990 Wabitsch M et al (2025) Impact of setmelanotide on metabolic syndrome risk in pediatric patients with POMC and LEPR deficiency

Stomach pain with Mounjaro is typically due to delayed gastric emptying

Children over 10 years old may also be prescribed Benzonatate, but dosing should be carefully managed by a healthcare provider

Inhibiting the enzyme is therefore investigated as a route to preserving both methyl donor pools and NAD+ availability, with downstream effects on sirtuin-dependent signaling