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Ceramides increase fatty acid utilization in intestinal progenitors to enhance stemness and increase tumor risk

This means that the clinical effectiveness of GSHand that of its precursors like NACis dependent not only on its capability to act as an antioxidant, but also the degree to which their pharmacodynamic properties are in line with the dysfunction in cellular signaling, redox imbalance, and immune response generated by specific disease states (Fraternale et al., 2021)

Therefore, NAC can promote the synthesis of GSH and replenish the antioxidant system, and plays a role in GSH depletion conditions, such as acetaminophen or organophosphate poisoning ( While NAC effectively replenishes GSH in GSH-deficient conditions, its ability to increase GSH levels under normal conditions is generally limited ( 2.2 Direct ROS scavenger NAC is a thiol compound that exhibits a high propensity for reacting with oxidants from a chemical thermodynamic perspective

10.1016/j.actbio.2013.07.030 132 XieP.YoungM